HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 4-(6-Acetylaminoindan-1-yl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Indane | HCID 10326 | — |
| Reactant | 6-Nitro-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 12318488 | — |
| Product | 4-(6-Acetylaminoindan-1-yl)butanoic acid | HCID 18545843 | — |
| Product | 2-(6-Acetylaminoindan-1-yl)acetic acid | HCID 18545899 | — |
| Product | 3-(6-Acetylaminoindan-1-yl)propanoic acid | HCID 18545930 | — |
Reaction Steps
2-(6-acetylaminoindan-1-yl)acetic acid, 3-(6-acetylaminoindan-1-yl)propanoic acid and 4-(6-acetylaminoindan-1-yl)butanoic acid were prepared from 6-nitro-1-indanecarboxylic acid by classical chain elongations by using KCN or diethyl malonate. The methodology is described for an analogous indane serie by R. Gruber et al. Tetrahedron 1974, 30, 3605-10. Alane was used for the reduction of the intermediate carboxylic acids.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06262087B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-aa238566599c4600aa21593557ff5098 |
| Source note | uspto-grants-2001_07 |