HRID1385072

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7761

Diethyl propanedioate

C7H12O4

HCID9032

Potassium cyanide

CKN

HCID10326

2,3-Dihydro-1H-indene

C9H10

HCID12318488

6-Nitro-2,3-dihydro-1H-indene-1-carboxylic acid

C10H9NO4

PRODUCTS

生成物

HCID18545843

未命名化合物

HCID18545899

未命名化合物

HCID18545930

未命名化合物

PROCEDURE

实验过程

2-(6-acetylaminoindan-1-yl)acetic acid, 3-(6-acetylaminoindan-1-yl)propanoic acid and 4-(6-acetylaminoindan-1-yl)butanoic acid were prepared from 6-nitro-1-indanecarboxylic acid by classical chain elongations by using KCN or diethyl malonate. The methodology is described for an analogous indane serie by R. Gruber et al. Tetrahedron 1974, 30, 3605-10. Alane was used for the reduction of the intermediate carboxylic acids.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa238566599c4600aa21593557ff5098
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06262087B1
来源说明: uspto-grants-2001_07

反应 SMILES

[N+](C1[CH:12]=[C:11]2C(CC[CH:10]2[C:13]([OH:15])=[O:14])=CC=1)([O-])=O.[C-]#[N:17].[K+].[C:19]([O:27]CC)(=[O:26])[CH2:20][C:21](OCC)=O.[CH2:30]1[C:38]2[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:32][CH2:31]1>>[C:13]([NH:17][C:36]1[CH:35]=[C:34]2[C:33]([CH2:32][CH2:31][CH:21]2[CH2:20][C:19]([OH:27])=[O:26])=[CH:38][CH:37]=1)(=[O:15])[CH3:10].[C:19]([NH:17][C:36]1[CH:37]=[C:38]2[C:33]([CH2:32][CH2:31][CH:30]2[CH2:11][CH2:10][C:13]([OH:15])=[O:14])=[CH:34][CH:35]=1)(=[O:27])[CH3:20].[C:19]([NH:17][C:36]1[CH:37]=[C:38]2[C:33]([CH2:32][CH2:31][CH:30]2[CH2:12][CH2:11][CH2:10][C:13]([OH:15])=[O:14])=[CH:34][CH:35]=1)(=[O:27])[CH3:20]