Bromine → 1-Acetyl-5-bromo-2,3-dihydro-3-[2-(methanesulphonyl)ethyl]-1h-indole
Reaction equation
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14][S:15]([CH3:18])(=[O:17])=[O:16])[CH2:5]1)(=[O:3])[CH3:2].[Br:19]Br>C(O)(=O)C.ClCCl>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:19])=[CH:10][CH:11]=2)[CH:6]([CH2:13][CH2:14][S:15]([CH3:18])(=[O:16])=[O:17])[CH2:5]1)(=[O:3])[CH3:2]Participants
5
Procedure
Bromination was done by treatment of 19a with bromine in a mixture of acetic acid and dichloromethane. The compound was an oil.
Sources & evidence
- ORD record
- ord-036d1b2a1306441cba02e701b057890d
- Source dataset
- uspto-grants-2001_07
- Patent number
- US06262087B1
Reaction notes
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