4-Pyridinemethanamine → HCID 15547422, compound

HRID 1385100Notes

Reaction equation

HRID 1385100 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15](Cl)=[O:16])[CH:13]=3)[C:8]([CH2:18][CH3:19])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>>[N:25]1[CH:26]=[CH:27][C:22]([CH2:21][NH:20][C:15]([C:12]2[CH:13]=[C:14]3[C:9]([C:8]([CH2:18][CH3:19])=[N:7][N:6]3[CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:10][CH:11]=2)=[O:16])=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 773174-PyridinemethanamineHCID 15545850HCID 15545850, compound

Product 1

HCID 15547422HCID 15547422, compoundYield 20.3%

Procedure

This compound was prepared according to the method of Example 15, using 51 mg (0.184 mmol, 1.0 equiv) 1-cyclopentyl-3-ethyl-1H-indazole-6-carbonyl chloride and 20 μL (0.193 mmol, 1.05 equiv) 4-(aminomethyl)pyridine as starting materials, to give 13 mg (20%) of white crystals: mp 147-149° C.; HRMS calcd for C21H24N4O+H: 349.2028. Found: 349.2031.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-5e0db419a1294ee992100b2a9d2dd6ad
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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