Bromocyclobutane → HCID 53784624, compound

HRID 1385106Notes

Reaction equation

HRID 1385106 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH2:14][CH3:15])=[N:10][NH:11]2)=[CH:7][CH:6]=1)=[O:4].[CH:16]1(Br)[CH2:19][CH2:18][CH2:17]1>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH2:14][CH3:15])=[N:10][N:11]2[CH:16]2[CH2:19][CH2:18][CH2:17]2)=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 78110BromocyclobutaneHCID 178438014HCID 178438014, compound

Product 1

HCID 53784624HCID 53784624, compoundYield 32.4%

Procedure

This compound was prepared according to the method of Preparation 3, using 750 mg (3.67 mmol, 1.0 equiv) 3-ethyl-1H-indazole-6-carboxylic acid methyl ester and 0.38 mL (4.04 mmol, 1.1 equiv) cyclobutyl bromide as starting materials to give 307 mg (32%) of a clear oil: HRMS calcd for C15H18N2O2+H: 259.1447. Found: 259.14550.

Workup

  1. customThis compound was prepared
  2. customaccording to the method of Preparation 3

Sources & evidence

ORD record
ord-dce07301f5604737a3977754792974bb
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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