2-Bromopropane → HCID 53710128, compound

HRID 1385107Notes

Reaction equation

HRID 1385107 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH2:14][CH3:15])=[N:10][NH:11]2)=[CH:7][CH:6]=1)=[O:4].Br[CH:17]([CH3:19])[CH3:18]>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([CH2:14][CH3:15])=[N:10][N:11]2[CH:17]([CH3:19])[CH3:18])=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 178438014HCID 178438014, compound

Product 1

HCID 53710128HCID 53710128, compoundYield 40%

Procedure

This compound was prepared according to the method of Preparation 3, using 750 mg (3.67 mmol, 1.0 equiv) 3-ethyl-1H-indazole-6-carboxylic acid methyl ester and 0.38 mL (4.04 mmol, 1.1 equiv) 2-bromopropane as starting materials to give 359 mg (40%) of a clear oil: HRMS calcd for C14H18N2O2+H: 247.1448. Found: 247.14530.

Workup

  1. customThis compound was prepared
  2. customaccording to the method of Preparation 3

Sources & evidence

ORD record
ord-56cbee09e91d48b99252c0fc270f9f60
Source dataset
uspto-grants-2001_07
Patent number
US06262040B1

Reaction notes

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