huagongshe.com
HRID1385755

反应详情

EQUATION

反应方程式

HRID 1385755 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)c1ccc(C(=O)O)s1
HCID20273

2,5-Thiophenedicarboxylic acid

C6H4O4S

结构：Cl.O=C(OCc1ccccc1)[C@H]1CCCN1
HCID22827650

未命名化合物

PRODUCTS

生成物

1
结构：O=C(OCc1ccccc1)[C@H]1CCCN1C(=O)c1ccc(C(=O)N2CCC[C@@H]2C(=O)OCc2ccccc2)s1
HCID53673751

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Using General Procedure A with 2.0 g (8.2 mmol) D-Proline benzyl ester hydrochloride and 700 mg (4.1 mmol) thiophene-2,5-dicarboxylic acid afforded, after flash chromatography (EtOAc), 1.84 g (84%) of the title compound as a yellow crystalline solid. MS m/e (%): 564 (M+NH4+, 70), 547 (M+H+, 100).

WORKUP

后处理

  1. customafforded