Hydrochloric Acid → HCID 53643571, compound

HRID 1385796Notes

Reaction equation

HRID 1385796 reaction equation
C([O:3][C:4]([C@H:6]1[CH:10]=[CH:9][CH2:8][N:7]1[C:11](=[O:28])[CH2:12][CH2:13][CH2:14][CH2:15][C:16]([N:18]1[CH2:22][CH:21]=[CH:20][C@@H:19]1[C:23]([O:25]CC)=[O:24])=[O:17])=[O:5])C.Cl>>[C:23]([C@H:19]1[CH:20]=[CH:21][CH2:22][N:18]1[C:16](=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][C:11]([N:7]1[CH2:8][CH:9]=[CH:10][C@@H:6]1[C:4]([OH:5])=[O:3])=[O:28])([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 54560943HCID 54560943, compound

Product 1

HCID 53643571HCID 53643571, compoundYield 118.9%

Procedure

0.09g (0.0002 mol) (R)-1-[6-[(R)-2-ethyloxycarbonyl-2,5-dihydropyrrole-1-yl]-6-oxo-hexanoyl]-2,5-dihydropyrrole-2-carboxylic acid ethyl ester were stirred with aqueous HCl at 50° C. for 3 hours. The solvent was evaporated and the residue dissolved in water and lyophilized to yield 0.08 g (97%) (R)-1-[6-[(R)-2-carboxy-2,5-dihydropyrrole-1-yl]-6-oxo-hexanoyl]-2,5-dihydropyrrole-2-carboxylic acid as light yellow foam. ISP-MS: 335 (M−H)−.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue dissolved in water

Sources & evidence

ORD record
ord-7d668a28dd78451ea497f9bf61d1f960
Source dataset
uspto-grants-2001_07
Patent number
US06262089B1

Reaction notes

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