Acetic Acid → HCID 131722765, compound

HRID 1385823Notes

Reaction equation

HRID 1385823 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH3:17][CH:18]([CH2:20][CH2:21][CH2:22][C@H:23]([C@@H:25]1[C@:43]2([CH3:44])[C@H:28]([C@H:29]3[C@H:40]([CH2:41][CH2:42]2)[C@:38]2([CH3:39])[C:32]([CH2:33][C@H:34]([CH2:36][CH2:37]2)[OH:35])=[CH:31][CH2:30]3)[CH2:27][CH2:26]1)[CH3:24])[CH3:19].C(O)(=O)C>O1CCCC1.[Pd]>[NH2:1][C@H:2]([C:4]([OH:6])=[O:5])[CH3:3].[CH3:19][CH:18]([CH2:20][CH2:21][CH2:22][C@H:23]([C@@H:25]1[C@:43]2([CH3:44])[C@H:28]([C@H:29]3[C@H:40]([CH2:41][CH2:42]2)[C@:38]2([CH3:39])[C:32]([CH2:33][C@H:34]([CH2:36][CH2:37]2)[OH:35])=[CH:31][CH2:30]3)[CH2:27][CH2:26]1)[CH3:24])[CH3:17]

Participants

5

Reactant 2

HCID 176Acetic AcidHCID 131722766HCID 131722766, compound

Product 1

HCID 131722765HCID 131722765, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Z-Ala-cholesterol (0.48 mmol) is placed in tetrahydrofuran (20 ml) and glacial acetic acid (3 ml) and hydrogenated in the presence of 5% palladium on charcoal for 2 hours. The reaction mixture is filtered and concentrated in vacuo.

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-fcb99a5c3ce44d078c1f5859c50d6e21
Source dataset
uspto-grants-2001_07
Patent number
US06264917B1

Reaction notes

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