Hydrochloric Acid → HCID 69637521, compound

HRID 1385836Notes

Reaction equation

HRID 1385836 reaction equation
[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1.[ClH:21]>>[ClH:21].[OH:1][CH:2]([CH2:16][NH:17][CH:18]([CH3:20])[CH3:19])[CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12941056HCID 12941056, compound

Product 1

HCID 69637521HCID 69637521, compound

Procedure

A solution of methyl 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenylacetate (563 mg, 2.00 mmol) in 6M hydrochloric acid (15 ml) was heated at 100° C. for 4 hours. The reaction mixture was concentrated (rotavapor) and the residue was taken up in water and lyophilised. 1H and 13C NMR spectra were in accordance with the structure and MALDI mass spectrometry gave a M+H at 268 as expected.

Workup

  1. concentrationThe reaction mixture was concentrated (rotavapor)
  2. customgave a M+H at 268

Sources & evidence

ORD record
ord-7e32ef4ec08044a5b8155757d310f71e
Source dataset
uspto-grants-2001_07
Patent number
US06264917B1

Reaction notes

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