Potassium Hydroxide → HCID 18518704, compound

HRID 1385974Notes

Reaction equation

HRID 1385974 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2([C:14]([O:16]C)=[O:15])[CH3:13])=[CH:5][CH:4]=1.[OH-].[K+]>CCO.O.O>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2([C:14]([OH:16])=[O:15])[CH3:13])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 70011850HCID 70011850, compound

Product 1

HCID 18518704HCID 18518704, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 19096565Water ethanolSolvent

Procedure

A mixture of 7-methoxy-1-methyltetralin-1-yl-carboxylic acid, methyl ester (0.67 g; 2.9 mmol; from step (ii) above) and KOH (4 g) in EtOH:H2O (1:1; 50 mL) was stirred overnight. The resultant mixture was diluted with water and extracted with ether. The aqueous layer was acidified (HCl) and extracted 3 times with ether. The combined organic layer was washed with water, dried (Na2SO4), and concentrated. Yield 0.58 g (81%).

Workup

  1. extractionextracted with ether
  2. extractionextracted 3 times with ether
  3. washThe combined organic layer was washed with water
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-22a0258e805d4670b25779a7387b58dd
Source dataset
uspto-grants-2001_07
Patent number
US06265397B1

Reaction notes

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