Dimethylformamide → HCID 70237496, compound

HRID 1386017Notes

Reaction equation

[C:1](=[O:4])([O-:3])[O-:2].[Cs+].[Cs+].BrC1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[CH:14]=[C:13](O)[CH:12]=[CH:11]2.[CH3:19][N:20](C)C=O>>[N:20]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:13][CH2:12][C@H:11]2[CH:10]=[CH:9][O:2][C:1](=[O:3])[O:4]2)[CH:19]=1

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 10796Cesium carbonate

HCID 271446-Bromo-2-naphthalenol

Product 1

HCID 70237496HCID 70237496, compound

Procedure

Prepared according to the method described in Example 1e) from cesium carbonate (13.7 g), 6bromo-2-naphthol (9.27 g) and a solution of (4S)-4-[2-(3-pyridyl)ethyl]-1,3-dioxin-2-one (7.3 g, Example 18d)) in dry N,N-dimethylformamide (100 ml) to give the title compound as beige crystals after recrystallisation from aqueous ethanol (9.14 g).

Workup

customPrepared

Sources & evidence

ORD record: ord-e887b0047d3d48789b62f63a5e864d43
Source dataset: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06265409B1

Reaction notes

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