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HRID1386021

反应详情

EQUATION

反应方程式

HRID 1386021 的结构方程式

REACTANTS

反应物

2
结构：[C-]#N.[Na+]
HCID8929

Sodium cyanide (Na(CN))

CNNa

结构：CC(C)(C)OC(=O)N1CCC[C@@]1(C)OS(C)(=O)=O
HCID86757172

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@@H]1CC#N
HCID10727173

未命名化合物

收率 30%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

To a solution of (R)-2-methanesulfonyloxy-methyl-pyrrolidine-1-carboxylic acid, tert-butyl ester (D3) (90 g, 0.32 mol) in DMF (1200 ml) was added sodium cyanide (24 g, 0.49 mol). Heated to 60° C. overnight. Reaction mixture was concentrated and partitioned between water and ether. The organic phase was dried and concentrated to give the title compound (18 g, 30%) (M-Boc) 110.

WORKUP

后处理

  1. customReaction mixture
  2. concentrationwas concentrated
  3. custompartitioned between water and ether
  4. customThe organic phase was dried
  5. concentrationconcentrated