反应详情

A mixture of 8-amino-2,3-dimethylimidazo[1,2-a]pyridine (0.7 g, 4.34 mmol), sodium carbonate (2.0 g), sodium iodide (0.3 g), 2,6-dimethylbenzylchloride (0.671 g, 4.34 mmol) and acetone (30 ml) was stirred overnight. The reaction mixture was filtered and the solvent was removed in vacuo. The residue was dissolved in methylene chloride and washed with aqueous NaHCO3. The organic layer was separated and the solvent was evaporated. The crude product was purified by flash chromatography eluting with CH2Cl2/MeOH to give 0.7 g of the title compound.

1. filtrationThe reaction mixture was filtered
2. customthe solvent was removed in vacuo
3. dissolutionThe residue was dissolved in methylene chloride
4. washwashed with aqueous NaHCO3
5. customThe organic layer was separated
6. customthe solvent was evaporated
7. customThe crude product was purified by flash chromatography
8. washeluting with CH2Cl2/MeOH