反应详情

A stirred mixture of 8-amino-2,3,6-trimethylimidazo[1,2-a]pyridine (0.5 g, 2.8 mmol), 2-ethyl-6-methylbenzaldehyde (0.45 g, 3 mmol) and zinc(II)chloride (0.4 g, 3 mmol) in 50 ml methanol was treated with sodium cyanoborohydride (0.19 g, 3 mmol) and refluxed for 20 h. The methanol was evaporated under reduced pressure and the residue was dissolved in dichloromethylene and water. The organic layer was separated, dried over sodium sulfate and evaporated under reduced pressure. The residue was chromatographed on silicagel with dichloromethylene:methanol (10:1) which yielded 0.28 g (33%) of the title compound.

1. temperaturerefluxed for 20 h
2. customThe methanol was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in dichloromethylene
4. customThe organic layer was separated
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure
7. customThe residue was chromatographed on silicagel with dichloromethylene:methanol (10:1) which