反应详情

A mixture of 8-amino-6-bromo-3-carboethoxy-2-methylimidazo[1,2-a]pyridine (2.06 g, 6.91 mmol), 2,6-dimethyl-4-fluorobenzylbromide (1.05 g, 4.48 mmol), sodium iodide (0.45 g), sodium carbonate (2.2 g) and acetone (40 ml) was refluxed for 22 h. The reaction mixture was filtered. The filtered material was washed with CH2Cl2. The methylene chloride solution was washed with water, dried and evaporated in vacuo. The residue was suspended in ethanol/ether and filtered to give 1.15 g (56%) of the title compound.

1. temperaturewas refluxed for 22 h
2. filtrationThe reaction mixture was filtered
3. washThe filtered material was washed with CH2Cl2
4. washThe methylene chloride solution was washed with water
5. customdried
6. customevaporated in vacuo
7. filtrationfiltered