反应详情

A mixture of 3-ethyl-1-fluoro-5-methylbenzene (1.1 g, 0.008 mol), paraformaldehyde (1.5 g, 0.05 mol), hydrobromic acid (4.1 ml 0.017 mol) (4.1 M in acetic acid) and acetic acid (2.5 ml) was stirred at ambient temperature for 40 h. To the mixture were water and petroleum ether (40-60) added and the organic layer was separated, washed with water, dried over anhydrous sodium sulfate and evaporated carefully under reduced pressure. The desired product was obtain as a yellow oil (1.3 g, 72%).

1. additionadded
2. customthe organic layer was separated
3. washwashed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated carefully under reduced pressure