反应详情

A solution of phloroglucinol dihydrate (20 g) and ethyl 2-benzylacetoacetate (27.5 ml) in ethanol (320 ml) was treated with dry HCl at 0° C. for five hours and the solution was kept at that temperature overnight. The yellow solution was concentrated and triturated with water, the solids filtered, washed with water and dried. The resulting hydrate was thrice evaporated to dryness from toluene, triturated with petroleum ether (bp. 40-60° C.) and filtered. Yield 33,4 g (96%). Melting point 258-260° C.

1. customwas kept at that temperature overnight
2. concentrationThe yellow solution was concentrated
3. customtriturated with water
4. filtrationthe solids filtered
5. washwashed with water
6. customdried
7. customevaporated to dryness from toluene
8. customtriturated with petroleum ether (bp. 40-60° C.)
9. filtrationfiltered