Hydrochloric Acid → HCID 20671943, compound

Participants

Reaction Conditions

Reaction Steps

2M Hydrochloric acid (40 ml, 80 mmol) was added to a solution of 4-(1-diethoxymethyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (3.7 g, 79 mmol), (prepared as described in Example 2), in ethanol (300 ml) at 80° C. A precipitate rapidly appeared which then went into solution followed after 15 minutes by the formation of a new precipitate. The mixture was stirred for 45 minutes at 80° C., the solid was collected by filtration, washed with ethanol and then ether and dried under vacuum at 65° C. to give 6-methoxy-7-2-methoxyethoxy)-4-(oxindol-3-yl)quinazoline (2.42 g, 84%) as a red orange solid.

Provenance & Evidence