Hydrochloric Acid → HCID 20671943, compound

HRID 1386250Notes

Reaction equation

HRID 1386250 reaction equation
Cl.C(OC(OCC)[N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21](OCCOC)=[C:22](OC)[CH:23]=3)[N:18]=[CH:17][N:16]=2)[C:7]1=[O:32])C>C(O)C>[NH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]([C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]=[CH:17][N:16]=2)[C:7]1=[O:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21717276HCID 21717276, compound

Product 1

HCID 20671943HCID 20671943, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

2M Hydrochloric acid (40 ml, 80 mmol) was added to a solution of 4-(1-diethoxymethyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (3.7 g, 79 mmol), (prepared as described in Example 2), in ethanol (300 ml) at 80° C. A precipitate rapidly appeared which then went into solution followed after 15 minutes by the formation of a new precipitate. The mixture was stirred for 45 minutes at 80° C., the solid was collected by filtration, washed with ethanol and then ether and dried under vacuum at 65° C. to give 6-methoxy-7-2-methoxyethoxy)-4-(oxindol-3-yl)quinazoline (2.42 g, 84%) as a red orange solid.

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed with ethanol
  3. dry with materialether and dried under vacuum at 65° C.

Sources & evidence

ORD record
ord-fd02f8f7de27451eb4ebc67ac46a3a51
Source dataset
uspto-grants-2001_07
Patent number
US06265411B1

Reaction notes

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