Hydrochloric Acid → HCID 21717270, compound

Participants

Reaction Steps

2M Hydrochloric acid (0.54 ml, 1.08 mmol) was added to a solution of 4-(1-diethoxymethyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (250 mg, 0.53 mmol), (prepared as described in Example 2), in ethanol (10 ml) at ambient temperature. A precipitate rapidly appeared. The mixture was stirred for 30 minutes, the solid was collected by filtration washed with ethanol and then ether and dried under vacuum at 60° C. to give 4-(1-formyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (141 mg, 68%) as an orange solid.

Provenance & Evidence