Hydrochloric Acid → HCID 21717270, compound

HRID 1386251Notes

Reaction equation

HRID 1386251 reaction equation
Cl.C([O:4][CH:5](OCC)[N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[CH:17][N:16]=2)[C:7]1=[O:32])C>C(O)C>[CH:5]([N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]([C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH2:28][CH2:29][O:30][CH3:31])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[CH:17][N:16]=2)[C:7]1=[O:32])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21717276HCID 21717276, compound

Product 1

HCID 21717270HCID 21717270, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2M Hydrochloric acid (0.54 ml, 1.08 mmol) was added to a solution of 4-(1-diethoxymethyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (250 mg, 0.53 mmol), (prepared as described in Example 2), in ethanol (10 ml) at ambient temperature. A precipitate rapidly appeared. The mixture was stirred for 30 minutes, the solid was collected by filtration washed with ethanol and then ether and dried under vacuum at 60° C. to give 4-(1-formyloxindol-3-yl)-6-methoxy-7-(2-methoxyethoxy)quinazoline (141 mg, 68%) as an orange solid.

Workup

  1. filtrationthe solid was collected by filtration
  2. washwashed with ethanol
  3. dry with materialether and dried under vacuum at 60° C.

Sources & evidence

ORD record
ord-debdc422babb48f5b122d3b06de1f6dd
Source dataset
uspto-grants-2001_07
Patent number
US06265411B1

Reaction notes

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