反应详情

A suspension of 6-methoxy-7-(4-pyridylmethoxy)-3,4-dihydroquinazolin-4-one (300 mg, 1.06 mmol) in thionyl chloride (5 ml) containing DMF (50 μl) was heated at reflux for 1 hour. The mixture was allowed to cool, diluted with toluene and the volatiles were removed by evaporation. The residue was dissolved in methylene chloride and a cooled solution of aqueous sodium hydrogen carbonate was added. The resulting precipitate was collected by filtration, washed with ether and dried under vacuum to give 4-chloro-6-methoxy-7-(4-pyridylmethoxy)quinazoline (175 mg, 55%).

1. temperaturewas heated
2. temperatureat reflux for 1 hour
3. temperatureto cool
4. customthe volatiles were removed by evaporation
5. dissolutionThe residue was dissolved in methylene chloride
6. additiona cooled solution of aqueous sodium hydrogen carbonate was added
7. filtrationThe resulting precipitate was collected by filtration
8. washwashed with ether
9. customdried under vacuum