反应详情

A solution of 6methoxy-7-(2-(pyrrolidin-1-yl)ethoxy)-3,4-dihydroquinazolin-4-one (228 mg, 7.9 mmol) in thionyl chloride (5 ml) and DMF (0.2 ml) was heated at reflux for 1 hour. Toluene was added and the volatiles were removed by evaporation. The residue was dissolved in methylene chloride and cooled aqueous sodium hydrogen carbonate solution was added. The organic layer was separated, washed with brine, dried (MgSO4) and the solvent removed by evaporation to give 4-chloro-6-methoxy-7-(2-(pyrrolidin-1-yl)ethoxy)quinazoline (200 mg, 82%).

1. temperatureat reflux for 1 hour
2. customthe volatiles were removed by evaporation
3. dissolutionThe residue was dissolved in methylene chloride
4. temperaturecooled aqueous sodium hydrogen carbonate solution
5. additionwas added
6. customThe organic layer was separated
7. washwashed with brine
8. dry with materialdried (MgSO4)
9. customthe solvent removed by evaporation