反应详情

7-benzyloxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (8.0 g, 22 mmol) was dissolved in TFA (40ml) and the mixture heated at reflux for 3 hours then allowed to cool to ambient temperature and stirred for 18 hours. The TFA was removed by evaporation and the residue resuspended in a mixture of ether and aqueous sodium hydrogen carbonate solution. The solid was collected by filtration, washed with water and ether and dried at 40° C. for 3 hours under high vacuum to give 7-hydroxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (5.42 g, 90%).

1. temperaturethe mixture heated
2. temperatureat reflux for 3 hours
3. customThe TFA was removed by evaporation
4. additionthe residue resuspended in a mixture of ether and aqueous sodium hydrogen carbonate solution
5. filtrationThe solid was collected by filtration
6. washwashed with water and ether
7. customdried at 40° C. for 3 hours under high vacuum