Hydrochloric Acid → HCID 21717251, compound

Participants

Reaction Steps

Using a procedure analogous to that described in Example 26, oxindole (0.32 g, 2.4 mmol) was added to sodium hydride (110 mg, 2.8 mmol) in DMF (15 ml) and the solution was treated with 4-chloro-6-morpholinoquinazoline (200 mg, 8 mmol), (EP 0566226), in DMF (8 ml). The product so obtained was treated with ethereal hydrogen chloride to give 4-(oxindol-3-yl)-6-morpholinoquinazoline hydrochloride (120 mg, 43%).

Provenance & Evidence