Hydrochloric Acid → HCID 21717251, compound

HRID 1386358Notes

Reaction equation

HRID 1386358 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[H-].[Na+].[Cl:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[CH:22]=2)[N:17]=[CH:16][N:15]=1.Cl>CN(C=O)C>[ClH:13].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[CH:22]=3)[N:17]=[CH:16][N:15]=2)[C:2]1=[O:10]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 321710OxindoleHCID 21717193153437-50-4

Product 1

HCID 21717251HCID 21717251, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

Using a procedure analogous to that described in Example 26, oxindole (0.32 g, 2.4 mmol) was added to sodium hydride (110 mg, 2.8 mmol) in DMF (15 ml) and the solution was treated with 4-chloro-6-morpholinoquinazoline (200 mg, 8 mmol), (EP 0566226), in DMF (8 ml). The product so obtained was treated with ethereal hydrogen chloride to give 4-(oxindol-3-yl)-6-morpholinoquinazoline hydrochloride (120 mg, 43%).

Workup

  1. customThe product so obtained

Sources & evidence

ORD record
ord-fbc129f796f140c683fb0e6418c5bfce
Source dataset
uspto-grants-2001_07
Patent number
US06265411B1

Reaction notes

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