HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → Dimethyl(3-(2-tetrahydropyranyl)oxy-2-oxoheptyl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Dimethyl (7-methoxy-3,3-dimethyl-2-oxoheptyl)phosphonate | HCID 15223961 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Dimethyl(3-(2-tetrahydropyranyl)oxy-2-oxoheptyl)phosphonate | HCID 54345769 | — |
Reaction Steps
The ketone (4) (1.95 g) was dissolved in toluene (150 ml), and ethylene glycol and p-toluenesulfonic acid (catalytic amount) were added. The solution was heated under reflux overnight while water produced was distilled off. After the usual work-up, ketal (5) was obtained. Yield: 1.8 g (84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265440B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-84e5251457064220a28c0fe2168342e9 |
| Source note | uspto-grants-2001_07 |