Hydrochloric Acid → HCID 86757183, compound

Participants

Reaction Steps

A solution of 0.547 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(2-pyridyl)ethanesulphonyl]-valerohydrazide in 5 ml of methanol was treated with 4 ml of a 1 M solution of hydrogen chloride in dioxan. The mixture was stirred at room temperature for 3 hours and evaporated. The residue was triturated with diethyl ether to give 0.463 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(2-pyridyl)ethanesulphonyl]valerohydrazide hydrochloride in the form of a white solid.

Provenance & Evidence