Hydrochloric Acid → HCID 86757183, compound

HRID 1386564Notes

Reaction equation

HRID 1386564 reaction equation
O1CCCCC1[O:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:41][CH:42]([CH3:44])[CH3:43])[C:22]([NH:24][N:25]([CH2:37][CH:38]([CH3:40])[CH3:39])[S:26]([CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)(=[O:28])=[O:27])=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:10].[ClH:45]>CO.O1CCOCC1>[ClH:45].[OH:7][NH:8][C:9]([C@H:11]([C@@H:21]([CH2:41][CH:42]([CH3:44])[CH3:43])[C:22]([NH:24][N:25]([CH2:37][CH:38]([CH3:39])[CH3:40])[S:26]([CH2:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][N:32]=1)(=[O:27])=[O:28])=[O:23])[CH2:12]/[CH:13]=[CH:14]/[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86757185HCID 86757185, compound

Product 1

HCID 86757183HCID 86757183, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.547 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(2-pyridyl)ethanesulphonyl]-valerohydrazide in 5 ml of methanol was treated with 4 ml of a 1 M solution of hydrogen chloride in dioxan. The mixture was stirred at room temperature for 3 hours and evaporated. The residue was triturated with diethyl ether to give 0.463 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-isobutyl-4-methyl-2′-[2-(2-pyridyl)ethanesulphonyl]valerohydrazide hydrochloride in the form of a white solid.

Workup

  1. customevaporated
  2. customThe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-84cd2db30774477fa202189c56b75251
Source dataset
uspto-grants-2001_07
Patent number
US06265446B1

Reaction notes

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