反应详情

A solution of 1-(4-n-Octyloxyphenyl)-4-tert-butoxycarbonylpiperazine (2.61 g) in trifluoroacetic acid (20 ml) was stirred for 4 hours at ambient temperature. The reaction mixture was evaporated under reduced pressure, and to the residue was added a mixture of 1N NaOH aqueous solution and ethyl acetate. The organic layer was taken, and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-(4-n-Octyloxyphenyl)piperazine (0.86 g).

1. customThe reaction mixture was evaporated under reduced pressure
2. additionto the residue was added
3. additiona mixture of 1N NaOH aqueous solution and ethyl acetate
4. dry with materialdried over magnesium sulfate
5. filtrationThe magnesium sulfate was filtered off
6. customthe filtrate was evaporated under reduced pressure