Hydrochloric Acid → HCID 17790869, compound

HRID 1386632Notes

Reaction equation

HRID 1386632 reaction equation
[CH:1]([C:4]1[C:12]([C:13](=[O:26])[CH:14]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:15][C:16]([O:18]C)=[O:17])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2].C(O)C.[OH-].[Na+].Cl>O>[CH:1]([C:4]1[C:12]([C:13](=[O:26])[CH:14]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:15][C:16]([OH:18])=[O:17])=[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][N:6]2[N:5]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 21183033HCID 21183033, compound

Product 1

HCID 17790869HCID 17790869, compoundYield 98.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound (1.58 g) of Example 25 was dissolved into ethanol (15 ml), and, after adding IN aqueous solution of sodium hydroxide (5 ml), the mixture was stirred for 1 hour at room temperature. water was added to the reaction liquor, then 10% hydrochloric acid was added to make pH 3, which was extracted with methylene chloride. After the organic layer was dried over anhydrous sodium sulfate, solvent was distilled off under reduced pressure to obtain aimed product (1.50 g) as colorless powder.

Workup

  1. extractionwas extracted with methylene chloride
  2. dry with materialAfter the organic layer was dried over anhydrous sodium sulfate, solvent
  3. distillationwas distilled off under reduced pressure

Sources & evidence

ORD record
ord-df5d5d9b40c64bb9b740e89f4fd7d521
Source dataset
uspto-grants-2001_07
Patent number
US06265577B1

Reaction notes

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