反应详情

The title compound was prepared from 23.2 mg (0.052 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-(3-fluorophenyl)pyrrolidin-1-yl)-3-(cyclobutyl)propanoic acid, benzyl ester (from EXAMPLE 26, Step A) and 12.8 mg (0.052 mmol) of 4-(3-phenylpropyl)piperidine.HCl using a procedure analogous to that described in EXAMPLE 1, Step J to provide 31.7 mg (96%) of the title compound: RF: 0.57 (1:1 v/v hexanes/EtOAc); 1H NMR (300 MHz) δ 1.13-3.27 (m, 33H), 5.14 (s, 2H), 6.86-6.99 (m, 3H), 7.14-7.38 (m, 11H).