HCID 21180662, compound → 2-(R)-(3-(S)-((4-(2,2-Dimethyl-3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

HRID 1386751Notes

Reaction equation

HRID 1386751 reaction equation
[C:1]1([CH2:7][C:8]([CH3:17])([CH3:16])[CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:18]([C@@H:20]1[C@@H:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:23][N:22]([C@H:31]([CH:44]2[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]2)[C:32]([O:34]CC2C=CC(OC)=CC=2)=[O:33])[CH2:21]1)=O>>[CH3:16][C:8]([CH3:17])([CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:9][CH:10]1[CH2:11][CH2:12][N:13]([CH2:18][C@@H:20]2[C@@H:24]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH2:23][N:22]([C@H:31]([CH:44]3[CH2:49][CH2:48][CH2:47][CH2:46][CH2:45]3)[C:32]([OH:34])=[O:33])[CH2:21]2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 21180662HCID 21180662, compoundHCID 53654320alpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl ester

Product 1

HCID 206723362-(R)-(3-(S)-((4-(2,2-Dimethyl-3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

Procedure

The title compound was prepared from 9 mg (0.05 mmol) of 4-(3-phenyl-2,2-dimethylpropyl)piperidine (from EXAMPLE 98, Step I) and 20 mg (0.05 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-methoxybenzyl ester (from EXAMPLE 33, Step E) using procedures analogous to those described in EXAMPLE 1, Step J and EXAMPLE 10, Step F. For the title compound: ESI-MS 531 (M+H).

Sources & evidence

ORD record
ord-37bcc8749e114e34a8c330d37034b0b5
Source dataset
uspto-grants-2001_07
Patent number
US06265434B1

Reaction notes

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