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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1386751Generated: October 29, 2026

HCID 21180662, compound → 2-(R)-(3-(S)-((4-(2,2-Dimethyl-3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid

https://huagongshe.com/reaction/1386751

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 21180662HCID 21180662—
Reactantalpha-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid 4-methoxybenzyl esterHCID 53654320—
Product2-(R)-(3-(S)-((4-(2,2-Dimethyl-3-phenylpropyl)piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acidHCID 20672336—

Reaction Steps

The title compound was prepared from 9 mg (0.05 mmol) of 4-(3-phenyl-2,2-dimethylpropyl)piperidine (from EXAMPLE 98, Step I) and 20 mg (0.05 mmol) of 2-(R)-(3-(R)-formyl-4-(S)-phenylpyrrolidin-1-yl)-2-(cyclohexyl)acetic acid, 4-methoxybenzyl ester (from EXAMPLE 33, Step E) using procedures analogous to those described in EXAMPLE 1, Step J and EXAMPLE 10, Step F. For the title compound: ESI-MS 531 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06265434B1
Source datasetuspto-grants-2001_07
ORD IDord-37bcc8749e114e34a8c330d37034b0b5
Source noteuspto-grants-2001_07