反应详情

A solution of 4-(3-(2,4-difluorophenyl)propyl)-1-t-butoxycarbonylpiperidine (90 mg, 0.27 mmol, from EXAMPLE 113, Step E) in 2 mL of 1% HCl in MeOH was heated to 50° C. for 2 h. After cooling to rt, the material was concentrated to provide 70 mg (93%) of the title compound: HPLC (YMC ODS-A 4.6×50 mm column, gradient elution using 10:90 v/v CH3CN/H2O+0.1% TFA to 100% CH3CN+0.1% TFA over 2.0 min, hold 1 min, 5.0 mL/min, 220 nm): Retention Time: 1.18 min.

1. concentrationthe material was concentrated