1-Bromo-2-propanol → 5-(2-Fluoro-4-iodophenylamino)-3-(2-hydroxypropyl)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
Reaction equation
[Br:50][CH2:51][CH:52]([OH:53])[CH3:54].[NH2:28][c:29]1[cH:30][cH:31][c:32]([NH:33][c:34]2[c:35]3[c:36](=[O:37])[nH:38][cH:39][n:40][c:41]3[n:42]([CH3:43])[c:44](=[O:45])[cH:46]2)[c:47]([F:48])[cH:49]1.[OH:1][CH:2]([CH2:3][n:4]1[cH:5][n:6][c:7]2[c:8]([c:9]1=[O:10])[c:11]([NH:17][c:18]1[c:19]([F:25])[cH:20][c:21]([I:24])[cH:22][cH:23]1)[cH:12][c:13](=[O:16])[n:14]2[CH3:15])[CH2:26][OH:27]>>[OH:1][CH:2]([CH2:3][n:4]1[cH:5][n:6][c:7]2[c:8]([c:9]1=[O:10])[c:11]([NH:17][c:18]1[c:19]([F:25])[cH:20][c:21]([I:24])[cH:22][cH:23]1)[cH:12][c:13](=[O:16])[n:14]2[CH3:15])[CH3:26]Participants
4
Sources & evidence
- ORD record
- ord-5a9b7c0b189a4f22a7859ffdefe87191
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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