HCID 131722813, compound → HCID 54467862, compound

HRID 1386780Notes

Reaction equation

HRID 1386780 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>CCO.[Pt]=O>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 131722813HCID 131722813, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54467862HCID 54467862, compoundYield 92.9%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

To a solution of 1 g of ((1-benzyl)piperidin-4-ylidene)acetic acid, t-butyl ester (from EXAMPLE 163, Step A) in 10 mL of EtOH was added 100 mg of platinum oxide at rt. The solution was hydrogenated for 3 h under one atmosphere of hydrogen gas. After filtering through celite, the filtrate was concentrated under reduced pressure to give 936 mg of the title compound as a viscous oil.

Workup

  1. filtrationAfter filtering through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-92f4dbb06c1d4c758a04bc9a1de17eaa
Source dataset
uspto-grants-2001_07
Patent number
US06265434B1

Reaction notes

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