HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium formate → 4-((1H-Benzimidazol-2-yl)methyl)piperidine HCOOH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-benzimidazole | HCID 14012845 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-((1H-Benzimidazol-2-yl)methyl)piperidine HCOOH | HCID 131722815 | 65.5% |
Reaction Steps
A mixture of 66 mg of 1-benzyl-4-((1H-benzimidazol-2-yl)methyl)piperidine (from EXAMPLE 164, Step A), 66 mg of 10% palladium on carbon and 68 mg of ammonium formate in 10 mL of MeOH was heated at reflux for 3 h. The mixture was cooled and filtered through celite. Concentration afforded 37 mg of the title compound as a foamy solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06265434B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-3d593a258b2447488d6e622e0c03f342 |
| Source note | uspto-grants-2001_07 |