反应详情

A mixture of 66 mg of 1-benzyl-4-((1H-benzimidazol-2-yl)methyl)piperidine (from EXAMPLE 164, Step A), 66 mg of 10% palladium on carbon and 68 mg of ammonium formate in 10 mL of MeOH was heated at reflux for 3 h. The mixture was cooled and filtered through celite. Concentration afforded 37 mg of the title compound as a foamy solid.

1. temperaturewas heated
2. temperatureat reflux for 3 h
3. temperatureThe mixture was cooled
4. filtrationfiltered through celite
5. concentrationConcentration