Hydrazine hydrate (1:1) → HCID 69829304, compound

HRID 1386941Notes

Reaction equation

HRID 1386941 reaction equation
C[O:2][C:3](=O)[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][F:12])=[CH:6][CH:5]=1.O.[NH2:15][NH2:16]>C(O)C>[F:12][CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([NH:15][NH2:16])=[O:2])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 44205335HCID 44205335, compound

Product 1

HCID 69829304HCID 69829304, compoundYield 1,010.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Fluoromethoxy-benzoic acid methyl ester (573 mg, 0.31 mmol) was dissolved in ethanol (10 ml) and heated under reflux with hydrazine monohydrate (0.8 ml, 1.55 mmol, 5 eq.) for 60 hrs. The volatiles were completely evaporated and the product was dried overnight under high vacuum at 40° C., to afford the title compound (577 mg, 100% yield) as a light brown solid. MS: m/e=184 (M+).

Workup

  1. temperatureheated
  2. customThe volatiles were completely evaporated
  3. customthe product was dried overnight under high vacuum at 40° C.

Sources & evidence

ORD record
ord-f6f8b33536a746bc9fee14352dfe7d8a
Source dataset
uspto-grants-2001_07
Patent number
US06265426B1

Reaction notes

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