2-(4-Methoxyphenyl)-3-(4-methoxyphenoxy)benzo[b]thiophene → 4-[[2-(4-Hydroxyphenyl)benzo[b]thiophen-3-yl]oxy]phenol

HRID 1386987Notes

Reaction equation

HRID 1386987 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25]C)=[CH:21][CH:20]=2)=[CH:5][CH:4]=1>CCOC(C)=O>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[C:10]=2[O:18][C:19]2[CH:20]=[CH:21][C:22]([OH:25])=[CH:23][CH:24]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 117930042-(4-Methoxyphenyl)-3-(4-methoxyphenoxy)benzo[b]thiophene

Product 1

HCID 106644494-[[2-(4-Hydroxyphenyl)benzo[b]thiophen-3-yl]oxy]phenolYield 87%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

By essentially following the procedure detailed in Example 5, Part B, the title compound was prepared from 2-(4-methoxyphenyl)-3-(4-methoxyphenoxy)benzo[b]thiophene (Part D) in 87% yield following radial chromatography (SiO2; 25% EtOAc in hexanes).

Sources & evidence

ORD record
ord-8be568f2b5414df185cfc1bcc1805223
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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