Benzo(B)Thiophene-2-Boronic Acid → HCID 21182740, compound

HRID 1386992Notes

Reaction equation

HRID 1386992 reaction equation
[S:1]1[C:5](B(O)O)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Br[C:14]1[CH:28]=[CH:27][C:17](/[CH:18]=[CH:19]/[C:20]([N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:21])=[CH:16][CH:15]=1>>[S:1]1[C:5]([C:14]2[CH:28]=[CH:27][C:17](/[CH:18]=[CH:19]/[C:20]([N:22]3[CH2:23][CH2:24][CH2:25][CH2:26]3)=[O:21])=[CH:16][CH:15]=2)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2

Participants

3

Reactant 2

HCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 898715HCID 898715, compound

Product 1

HCID 21182740HCID 21182740, compoundYield 43%

Procedure

By essentially following the procedure detailed in Example 1, Part B, the title compound was prepared from benzo[b]thiophene-2-boronic acid and 1-(trans-4-bromocinnamoyl)pyrrolidine (Part A) in 43% yield following chromatography.

Sources & evidence

ORD record
ord-054aca82bde9487099cabd1f0ee6c95e
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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