3,4-Difluorobenzoyl chloride → 6-Benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-Difluorophenyl Ketone

HRID 1387022Notes

Reaction equation

HRID 1387022 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[CH:16]=[C:15]([N:17]([CH3:19])[CH3:18])[S:14][C:13]=2[CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[F:31])[C:25](Cl)=[O:26]>>[F:21][C:22]1[CH:23]=[C:24]([C:25]([C:16]2[C:12]3[CH:11]=[CH:10][C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:20][C:13]=3[S:14][C:15]=2[N:17]([CH3:18])[CH3:19])=[O:26])[CH:28]=[CH:29][C:30]=1[F:31]

Participants

3

Reactant 2

HCID 27245193,4-Difluorobenzoyl chlorideHCID 106129946-Benzyloxy-2-dimethylaminobenzo[b]thiophene

Product 1

HCID 211826236-Benzyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 3,4-Difluorophenyl KetoneYield 95%

Procedure

The title compound (oil) was prepared in 95% yield from 6-benzyloxy-2-(dimethylamino)benzo[b]thiophene and 3,4-difluorobenzoyl chloride by essentially following the procedure outlined in Example 81, Part C.

Sources & evidence

ORD record
ord-185ede9e4dc54d719e43e0352b76d413
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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