Dimethylamine → rac-(1R,2R)-2-(dimethylamino)cyclohexan-1-ol

Temperature

0 °C

To a solution of cyclohexene oxide (3.64 mL, 36.0 mmol) in 30 mL of dry methanol was added dropwise 2.0 M dimethylamine in THF (15.0 mL, 30.0 mmol). The reaction mixture was stirred at 0° C. for 4 h. The solution was then warmed to room temperature and stirred for 18 h. The reaction mixture was then concentrated under reduced pressure to afford 1.11 g (26% crude yield) of the crude product which was used in the following reaction without purification.

1. temperatureThe solution was then warmed to room temperature
2. stirringstirred for 18 h
3. concentrationThe reaction mixture was then concentrated under reduced pressure

ORD record

ord-b5d47270940b4bc6b4aa2679cdc0ae0a

Source dataset

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06265575B1