6-Allyloxy-2-(dimethylamino)benzo[b]thiophene → 6-Allyloxy-2-(dimethylamino)benzo[b]thiophen-3-yl 4-(Dimethylamino)methyl-3-methoxyphenyl Ketone
Reaction equation
[CH2:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]2[CH:12]=[C:11]([N:13]([CH3:15])[CH3:14])[S:10][C:9]=2[CH:16]=1)[CH:2]=[CH2:3].[CH3:17][N:18]([CH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](O)=[O:26])=[CH:23][C:22]=1[O:30][CH3:31])[CH3:19]>>[CH3:19][N:18]([CH2:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([C:12]2[C:8]3[CH:7]=[CH:6][C:5]([O:4][CH2:1][CH:2]=[CH2:3])=[CH:16][C:9]=3[S:10][C:11]=2[N:13]([CH3:14])[CH3:15])=[O:26])=[CH:23][C:22]=1[O:30][CH3:31])[CH3:17]Participants
3
Procedure
The title compound was prepared in 73% yield (23% SM recovered) by essentially following the procedures outlined in Example 84, Part A from 6-allyloxy-2-(dimethylamino)benzo[b]thiophene (Part B) and 4-(dimethylamino)methyl-3-methoxybenzoic acid (Part D).
Sources & evidence
- ORD record
- ord-0571af7749194955ac52f32a1dce86ae
- Source dataset
- uspto-grants-2001_07
- Patent number
- US06265575B1
Reaction notes
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