Hydrochloric Acid → HCID 69690754, compound

Participants

Reaction Steps

A solution of methyl 3-methyl-4-[(1-pyrrolidinyl)methyl]benzoate (16 g, 68.6 mmol) in 250 mL of 1 N HCl was heated at reflux overnight (13 hr). After cooling to ambient temperature, the aqueous solution was extracted with EtOAc (150 mL). The aqueous layer was concentrated by rotary evaporation to give 16.8 g (65.7 mmol; 96%) of the title acid as a white solid.

Provenance & Evidence