Hydrochloric Acid → HCID 69690754, compound

HRID 1387056Notes

Reaction equation

HRID 1387056 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)[C:5]([O:7]C)=[O:6].[ClH:18]>>[ClH:18].[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)[C:5]([OH:7])=[O:6]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22462656HCID 22462656, compound

Product 1

HCID 69690754HCID 69690754, compound

Procedure

A solution of methyl 3-methyl-4-[(1-pyrrolidinyl)methyl]benzoate (16 g, 68.6 mmol) in 250 mL of 1 N HCl was heated at reflux overnight (13 hr). After cooling to ambient temperature, the aqueous solution was extracted with EtOAc (150 mL). The aqueous layer was concentrated by rotary evaporation to give 16.8 g (65.7 mmol; 96%) of the title acid as a white solid.

Workup

  1. temperatureat reflux overnight (13 hr)
  2. extractionthe aqueous solution was extracted with EtOAc (150 mL)
  3. concentrationThe aqueous layer was concentrated by rotary evaporation

Sources & evidence

ORD record
ord-e4f418ac176e43c8b4e7013390fa90fc
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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