HRID1387071

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID971

Oxalic acid

C2H2O4

反应SMILES：O=C(c1ccc(CN2CCCC2)c(Br)c1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2cc(O)ccc12

HCID21182697

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(O)C(=O)O.O=C(O)C(=O)O.O=C(c1ccc(CN2CCCC2)c(Br)c1)c1c(-c2ccc(OCCN3CCCC3)cc2)sc2cc(O)ccc12

HCID86757215

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

2 次

PROCEDURE

实验过程

4-[3-Bromo-4-[(1-pyrrolidinyl)methyl]phenyl 6-hydroxy-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone (Part E) (19 mg; 31 μmol), was dissolved in 3 mL of ethyl acetate. Oxalic acid (7 mg; 79 μmol) in 1 mL of EtOAc was added. The resultant slurry was subjected to centrifugation and the supernatant was decanted. Fresh EtOAc (4 mL) was added and the process was repeated two more times. The solid product was dried in vacuo overnight.

WORKUP

后处理

customthe supernatant was decanted
additionFresh EtOAc (4 mL) was added
customThe solid product was dried in vacuo overnight

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e301153490834e25b85d91eae7c0ff76
来源数据集: uspto-grants-2001_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06265575B1
来源说明: uspto-grants-2001_07

反应SMILES

[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)=[C:14]([Br:24])[CH:13]=3)=[O:11])=[C:8]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][N:34]4[CH2:38][CH2:37][CH2:36][CH2:35]4)=[CH:27][CH:26]=3)[S:7][C:6]=2[CH:39]=1.[C:40]([OH:45])(=[O:44])[C:41]([OH:43])=[O:42]>C(OCC)(=O)C>[C:40]([OH:45])(=[O:44])[C:41]([OH:43])=[O:42].[C:40]([OH:45])(=[O:44])[C:41]([OH:43])=[O:42].[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)=[C:14]([Br:24])[CH:13]=3)=[O:11])=[C:8]([C:25]3[CH:30]=[CH:29][C:28]([O:31][CH2:32][CH2:33][N:34]4[CH2:38][CH2:37][CH2:36][CH2:35]4)=[CH:27][CH:26]=3)[S:7][C:6]=2[CH:39]=1