Dimethylamine → HCID 21182833, compound

HRID 1387075Notes

Reaction equation

HRID 1387075 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12]Br)[C:5]([O:7][CH3:8])=[O:6].[CH3:14][NH:15][CH3:16]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[CH2:12][N:15]([CH3:16])[CH3:14])[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 10804694Methyl 3-bromo-4-(bromomethyl)benzoate

Product 1

HCID 21182833HCID 21182833, compoundYield 70%

Procedure

By following essentially the procedure of Example 137, Part B, the title compound was prepared from methyl 3-bromo-4-bromomethylbenzoate (Example 137, Part A) and dimethylamine (40%), in 70% yield. The flash chromatography was carried out by eluting with a gradient of hexanes(100-80%)/EtOAc(0-20%).

Workup

  1. washby eluting with a gradient of hexanes(100-80%)/EtOAc(0-20%)

Sources & evidence

ORD record
ord-945f748f00d44130b1c7f98aec74c142
Source dataset
uspto-grants-2001_07
Patent number
US06265575B1

Reaction notes

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